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RESEARCH VENOM PROTEASES NOTECHIS SCUTATUS VENOM SNAKE

Notecarin

Product derived from the venom of Notechis scutatus in frozen form.
MW(Da) : 54 000 The prothrombin activator present in the venom of the mainland tiger snake venom (Notechis scutatus) is capable of cleaving the Arg274-Thr275 and Arg323-Ile324 bonds of bovine prothrombin. Prethrombin and meizothrombin occur as intermediates during prothrombin activation. This venom activity on prothrombin is greatly stimulated by the presence of Ca2+, phospholipid and FVa.

Reference	Presentation	Packaging
6-VEN-NOTE-100	Vial	50 µg

Price list, safety data sheets and notices are accessible to our registered customers.

Snake venom proteases are useful tools for studying coagulation reactions. Venoms contain more than 20 different compounds, mostly proteins and polypeptides. Some of the proteins in snake venom have very specific effects on various biological functions including blood coagulation, blood pressure regulation, transmission of the nervous or muscular impulse and have been developed for use as diagnostic tools. Plasma coagulation Factors are usually inactive and require proteolytic activation as a first step towards a chronometric or colorimetric assay. It is often advantageous to use specific enzymes from snake venoms to activate coagulation Factors rather than physiological activators. In contrast to other activators, many snake venom enzymes are not dependent from cofactors, phospholipid or calcium ions.

All of our venom products are supplied in 50 % glycerol / water for storage at -20° C or supplied lyophilized at 2-8° C. Expiry date = 1 year

The venom proteases offered are highly purified, homogenous preparations with the indicated activities.

	These kits are manufactured in accordance with the 98/79 EC directive for in vitro diagnostic devices. Only CE marked products can be used for diagnostic applications in Europe.
	These kits are intended for in vitro diagnostic use.
	These kits are for research use only and are not intended to be used for diagnostic procedures.
	Federal Drug Administration, FDA validates diagnostic kits for in vitro diagnostic use in the United States.
	Biological risk products.
	Storage between 2 and 8 ° C.
	Reactive in liquid form.
	Reactive in lyophilized form.
	Reactive in frozen form.
	Stability after opening at 2-8 ° C.
	Products that can be refrozen.
	Stability 12 months after refreezing at -20 ° C.
	Manufacturer.
	Importer
	Distributor.

RESEARCH VENOM PROTEASES NOTECHIS SCUTATUS VENOM SNAKE

Notecarin

Price list, safety data sheets and notices are accessible to our registered customers.

Cryopep Catalogue
Thrombosis Haemostasis 2023

Cryopep Catalogue
Haemostasis Research 2023

Cryopep VENOM PROTEASES

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Notecarin

Product sheet

Price list, safety data sheets and notices are accessible to our registered customers.