Plasminogen activator inhibitor 1 (PAI-1) is a glycoprotein, the primary inhibitor of t-PA and u-PA. It plays an essential role in controlling any excessive activation of fibrinolysis. It is present in plasma associated with vitronectin, in free form or associated with t-PA and in the alpha granules of platelets. Fibrinolysis corresponds to the solubilization of the fibrinous thrombus by plasmin, an enzyme derived from plasminogen adsorbed to fibrin. Plasminogen is activated by t-PA and u-Pa. PAI-1 by inhibiting plasminogen activators, it controls the degradation of fibrinous thrombus. A decrease in fibrinolytic activity promotes the occurrence of thrombosis, while excessive fibrinolysis leads to hemorrhages.
Lyophilized antibody in a buffer composed with 0,15M PBS and 0,02% sodium azid. Antibody to be reconstituted with 0,5mL of distilled water to aliquot and store at -20°C.
The lyophilized presentation allows greater stability until the expiration date.
