These kits are manufactured in accordance with the 98/79 EC directive for in vitro diagnostic devices. Only CE marked products can be used for diagnostic applications in Europe.
These kits are intended for in vitro diagnostic use.
These kits are for research use only and are not intended to be used for diagnostic procedures.
Federal Drug Administration, FDA validates diagnostic kits for in vitro diagnostic use in the United States.
Biological risk products.
Storage between 2 and 8 ° C.
Reactive in liquid form.
Reactive in lyophilized form.
Reactive in frozen form.
Stability after opening at 2-8 ° C.
Products that can be refrozen.
Stability 12 months after refreezing at -20 ° C.
Donor under Coumadin® treatment
Plasma collected by plasmapheresis at FDA approved donor centers.
Anticoagulant : 3.2 % Sodium citrate
1 x 1.0 mL
Price list, safety data sheets and notices are accessible to our registered customers.
Warfarin (Coumadin) is an antithrombotic agent from the group of anti-vitamin K (AVK).
In plasma, it is strongly bound to albumin (97%). Only the free fraction is active and metabolized. AVKs are involved in the hepatocyte in the vitamin K reduction mechanism.
Reduced vitamin K is the cofactor of a carboxylase which converts glutamic acid to gamma-carboxyglutamic acid which is necessary for the attachment of certain coagulation factors to phospholipid surfaces.
AVKs have an indirect anticoagulant effect by preventing the synthesis of the active forms of several coagulation factors (factors II, VII, IX, X).
When administered orally, VKA induce hypoprothrombinemia within 36 to 72 hours. After stopping the AVK, the anticoagulant action persists for 4 days, the speed of correction being a function of the hepatic synthesis capacities of vitamin K-dependent coagulation factors and the half-life of the AVK.
The times indicated may be prolonged, in particular in the elderly. The half-life of warfarin is in the range of 35 to 45 hours.
Special plasmas are derived from patients with a congenital deficiency, severe or moderate, or presenting a particular profile. No buffer or preservatives are added.
Store at -80/-40°C, stable until date stated on vial label when stored at -80/-40°C.
After thawed, stable during 4 hours at +2/+8°C in original vial.
No additive or preservative.
Expiry date > 1 year.