Tissue plasminogen activator (t-PA) is a serine esterase that plays a key role in the fibrinolysis system. It is present in plasma, 95% bound to PAI-1, in platelets and in some tissues. In plasma, the enzymatic activity of t-PA on plasminogen is very low, it is amplified 200 to 400 times when t-PA and plasminogen are adsorbed to fibrin.
Plasminogen activator inhibitor (PAI-1) is a glycoprotein, the primary inhibitor of t-PA and u-PA. It plays an important role in controlling excessive fibrinolysis. PAI-1 is mainly synthesized by vascular endothelial cells, as well as by other cells (hepatocyte, CML, fibroblasts, etc.). It circulates in plasma in 3 forms: an active form linked to vitronectin, a latent free form and an inactive form. By inhibiting t-PA and u-PA, PAI-1 limits the activation of plasminogen and controls the degradation of fibrinous thrombus.
Packaging in plastic cryotubes or in bottles of at least 100 mL.
The frozen, immuno-depleted plasmas are certified to have less than 1% for the deficient factor considered, both for the antigenic assay and for functional hemostasis.
- No bovine additives
- No reconstitution error
- No deterioration of plasmas linked to freeze-drying
- Cryotubes ready to use after thawing (4 min at 37°C).
- 10 cryotubes x 1 mL or 100 mL vial of frozen plasma.