Phospholipids constitute a catalytic surface for the enzymatic activation of coagulation factors.
Lupus circulating anticoagulants are heterogeneous autoantibodies of the IgG and IgM type directly directed against a variety of anionic phospholipids such as cardiolipin, phosphatidylserine or phosphatidylinositol or against proteins having the capacity to bind to phospholipids such as β2-glycoprotein I (β2 -GPI).
The contribution of phospholipids (PL) does not modify the levels of factors VIII, IX, XI, XII on normal plasmas without deficit nor LA.
The contribution of PL does not modify the levels of factors VIII, IX, XI, XII on the known deficient plasmas with and without LA (isolated constitutional or acquired deficiency)
The supply of PL leads to an increase in factors VIII, IX, XI, XII in plasmas with LA.
This solution can be used in hemostasis tests and for the neutralization of circulating lupus anticoagulants.
Molar concentration :
Phosphatidyl choline: 42% (synthetic)
Phosphatidyl serine : 28% (synthetic)
Sphingomyelin : 30% (egg yolk)
Expiration date of 30 months from the date of manufacture with storage at 2 °C / 8 °C.
For use in all hemostasis tests and neutralization of circulating lupus coagulants. Solution specially designed for the global NAPT method. A coagulation time of approximately 250s is obtained with the phospholipid solution, depending on the instrument used.
For the determination of pro and anticoagulant proteins, this solution is useful for all methods integrating phospholipids such as FII, FVIII, FIX, FX, Proteins C and S..
